SEO rank with no keywords in domain?

A website's name is the very first thing that is to be taken into consideration to determine a website's success. However, and this is especially true when creating a brand, it's not always possible to include related keywords in your domain (price is one of the many causes, but it can also simply be due to personal preference).

Can a website still be successful in a specific niche if no related keywords are contained in the domain, despite them being promoted through the website's metatags, articles and whatnot?